Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: A preliminary study
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چکیده
منابع مشابه
Platelet Alpha-2-Adrenergic Symptom Schizophrenia: A Preliminary Study Dysfunction in Negative
The specific binding to platelet membranes (B~,) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment B,~,~ for 3H-clonidine showed a significantly smaller change in B~,~ after treatment, less improvement in their cl...
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The specific binding to isolated platelet membranes of 3H-clonidine, an alpha 2-adrenergic receptor partial agonist, and 3H-yohimbine, an alpha 2-adrenergic receptor antagonist, was measured in male, drug-free schizophrenic patients. The maximum number of binding sites (Bmax) for 3H-yohimbine was significantly lower in these patients than in normal subjects. Treatment with chlorpromazine (CPZ) ...
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To study the aggregation, adhesion, and specific binding of an alpha 2-antagonist, [3H]rauwolscine, to the platelet membrane fractions, platelets were obtained from 30 patients with essential hypertension and nine normotensive subjects fed a high sodium diet (NaCl, 16-18 g/day) for 7 days and thereafter a low sodium diet (NaCl, 1-3 g/day) for 7 days. The patients with essential hypertension wer...
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Adrenergic receptor dysregulation has been described as occurring in both major depressive disorder (MDD) and panic disorder. Measurements of platelet alpha 2 adrenergic receptors in these patients may be confounded by the coexistence or comorbidity of both diagnoses in the same patient. To explore this possibility, we measured platelet alpha 2 adrenergic receptors (3H-clonidine and 3H-yohimbin...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 1985
ISSN: 0006-3223
DOI: 10.1016/0006-3223(85)90025-3